Purpose: The concept of supplication is one of the basic elements of spiritual education and one of the moral concepts in the Holy Quran. The present study seeks to find out what semantic components supplication has according to the syntagmatic relation and also what it has to do with spiritual health.
Materials and Methods: The present study has been done using library-citation method and qualitative analysis in the form of  (descriptive-analytical) content analysis and semantic analysis focusing on syntagmatic relation.
Findings: The quality of supplication and its underlying factors provide a complete package to improve spiritual health and the desired perfection so that in severe critical situations, human beings do not undergo anxiety, stress, physical, mental and social diseases. At this point a person's spiritual dimension dominates other dimensions and makes suffering meaningful so that the person reaches the desirable life offered by the Qur'an.
Conclusion: The results of the research indicate when it comes that this word is in association with the Arabic words (Azab), (Zara), (Basa), (Estekanat), All these four concepts are considered to be an introduction that come before supplication. There's also another syntagmatic relation, (Khofie) Which represents secrecy in prayer. It can be used to best explain the meaning of syntagmatic relations and (Khefie)  would be another word for syntagmatic relations which means "fear" that can be a ground for supplication. It also indicates the quality of supplication. Ultimately, all these components will have a direct impact on a person's spiritual health and can direct a person to the desired objective the holy Quran recommends.