Jihad is a well-known and holy concept in our religious literature and is one of the important chapters of Islamic jurisprudential books. One of the types of jihad is the great jihad, which falls under the category of minor jihad. The Great Jihad has a completely Quranic nature and verse 52 of Surah Al-Furqan indicates this. This jihad means disobeying the enemy in various fields of politics, culture, society, and the field of economy. The purpose of this study is to examine the nature of the Great Jihad in the Quran and hadiths and to count the ways in which the enemy operates in order to find solutions to cope with it in the field of economics. The methodology of this research is descriptive-analytical and the method of data collection is through the library. The data collection tools include taking notes from books, articles and software. The findings of this study indicate the need for the country's immunity from the harms and enmities of long-standing and vindictive enemies, and it is necessary for us to consider all four areas of the Great Jihad and do our best to advance the goals of these areas. Since the enemy uses the two methods of infiltration and sanctions to destroy the economy of the target societies, so the solution of the great jihad in the field of economy is not to be digested in the economy of the world community and to implement the resistance economy