Aims: As many references indicate, fasting has sometimes been deemed as a trigger for the dry eye syndrome. The aim of this study was to investigate the probable influence of fasting on the dry eye syndrome occurrence by integrating data published on tear proteome change in fasting people, patients with diabetes, smokers, and dry eye patients.
Information & Methods: In this systematic review, for document extraction, the document-deduction method (database review and data extraction from the selected studies in accordance with the defined inclusion criteria) was used. Finally, 6 documents were introduced as reference documents for data extraction.
Findings: In the studies of the Gross Research Group, the tear proteins in individuals with susceptible to dry eye (patients with diabeties and smokers) did not show any significant changes compared to healthy subjects. While in the study, the tear proteins and especially lysozyme and lactoferrin were decreased in the tears of the fasting eyes. In the research group, there were two additional couriers in the chromatogram pattern of fasting people, but this increase was not reported in the electrophoresis pattern. The study conducted by Krimoglu's team also showed that the change in the water pattern could cause temporary tear secretion in fasting people.
Conclusion: Despite slight differences in the content of tear proteins in the eyes of fasting people, the control group, and those susceptible to dry eye, probably the difference in tear protein content of fasting and healthy individuals cannot be a factor in the constant induction of dry eye in fasting individuals, and the feeling of dryness in the eye during fasting periods is associated with temporary water loss.