Introduction: One of the interpretive methods is the scientific interpretation method and one of the dimensions of the miracle of the Qur'an is its scientific miracle. One of the decrees in the Holy Qur'an is avoiding the sexual intercourse with women in the menstruation period. The problem that this research seeks to answer is that, in light of the medical achievements and using the medical interpretation method, as one of the scientific interpretation methods, how one can interpret the verse 222 of Al-Baqarah Surah (which deals with this issue) and justify the reason for such a decree. Therefore, the present study was conducted with the aim of medical interpretation of verse 222 of Al-Baqarah Surah on medical reasons to prevent sexual intercourse with women in menstruation period. Conclusion: It is clear from the medical interpretation of verse 222 of Al-Baqarah Surah that, regarding the adverse mental and physical effects of sexual intercourse in the menstruation period on men and women, the prohibition of the sexual intercourse with women in menstruation period is completely wise. Not only sexual intercourse in the menstruation period is hateful, but also it has many disadvantages, including the likelihood of male and female sterilization, the creation of an environment conducive to the development of microbes of sexual diseases (such as syphilis and gonorrhea), inflammation of the female reproductive organs, and the entrance of contaminated blood into the male reproductive organ. In fact, avoiding sexual intercourse with women in menstruation period is confirmed based on the trusted achievements of medical science, which is one of the dimensions of the scientific miracle of the Holy Qur'an.