The personality of each person expresses his fixed thought, emotional and behavioral patterns. Perceptions and thoughts of each person call for appropriate behavior and affect relationships with others. Accordingly, mental health and human relationships are always affected by personality and its injuries, and this effect is higher in the pathology of narcissism. This article is written with the aim of representing the concept of narcissism and its role on mental health and human relationships and how these two affect each other and providing strategies to reduce it from the perspective of the Qur'an using the method of content analysis. He used the results of psychology and educational science research and explained the topic by referring to Quran and Hadith and presented Quranic strategies to achieve it and stated that: the closest concept to the meaning of narcissism in the Holy Quran is Kabir. Arrogance and narcissism share many symptoms and have almost the same behavior pattern. The most important functions of narcissism are: changes in self-esteem, increase in aggression, increase in sense of entitlement, decrease in empathy, decrease in self-control, which endangers a person's mental health and creates problems in the person's mental health, prevents a person from establishing favorable and beneficial relationships, creating problems in establishing relationships, has caused more damage and problems for mental health, which in turn causes more and more destruction and loss of relationships. Among the most important strategies of the Quran to reduce narcissism can be mentioned: changing cognition, practicing humility and remembering death. Following these strategies can remove a person from the position of arrogance and narcissism and be a factor for mental health and thus the health of human relationships.